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1996-03-04
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Document 0595
DOCN M9640595
TI [Clinical manifestations and course of cytomegalovirus colitis in AIDS
patients]
DT 9604
AU Giezendanner S; Wirth HP; Zala G; Weber R; Flury R; Meyenberger C;
Abteilung fur Gastroenterologie, Universitatsspital Zurich.
SO Schweiz Med Wochenschr. 1995 Dec 16;125(50):2417-22. Unique Identifier :
AIDSLINE MED/96135388
AB The clinical findings and course in 10 HIV-positive patients with
cytomegalovirus (CMV) colitis were analyzed. Homosexuality was the main
risk factor for HIV infection. All patients had markedly reduced CD4
counts (mean 25 x 10(9)/l). Symptoms at presentation were chronic
diarrhea, weight loss, fever and abdominal pain. One of the patients had
an abdominal mass in the ileocecal region due to inflammation as the
leading symptom. Endoscopically the colitis was more often segmental
than diffuse. In 2 out of 9 patients who underwent colonoscopy, only the
right hemicolon was affected. Concurrent intestinal infections with up
to 4 different pathogens were found in 7 patients. 5 patients had
chorioretinitis as an extraintestinal CMV symptom (2 before, 3 after the
occurrence of CMV-colitis). In only one patient was there a partial
response of CMV-colitis to therapy with ganciclovir and foscarnet. Even
under therapy CMV colitis was complicated in 2 patients by perforation
and inflammatory stenosis respectively. Both needed surgical treatment.
Most of the patients died of generalized CMV infection or wasting
syndrome.
DE Adult Antiviral Agents/THERAPEUTIC USE AIDS-Related Opportunistic
Infections/*VIROLOGY Cohort Studies Colitis/DIAGNOSIS/*VIROLOGY
Colonoscopy Cytomegalovirus/ISOLATION & PURIF Cytomegalovirus
Infections/*COMPLICATIONS/DIAGNOSIS/DRUG THERAPY Cytomegalovirus
Retinitis/COMPLICATIONS English Abstract Foscarnet/THERAPEUTIC USE
Ganciclovir/THERAPEUTIC USE Human HIV Infections/*COMPLICATIONS Male
Middle Age Retrospective Studies JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).